As of May 24, 2022, the developers have released WordPress 6.0. WordPress 6.0 (Arthuro) includes more than 500 improvements and 400 bug fixes according to the release notes. I just updated one blog – so far I couldn't find any problems or bugs. A Multisite blog (this blog belongs to), on the other hand, says that another update is in progress. I have then run the update in English (instead of German), which worked.